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KMID : 0895820080180030041
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Journal of Oriental Rehabilitation Medicine
2008 Volume.18 No. 3 p.41 ~ p.49
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Inhibitory Effect of Daesiho-tang(Dachaihu-tang) Extracts on High-fat Diet-induced Obesity
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Song Mi-Young
Kim Eun-Kyung
Shin Byung-Cheul
Lee Jeong-Han
Kong Jae-Cheol
Ryu Do-Gon
Kwon Kang-Beom
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Abstract
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Objectives :The aim of this study is to investigate Daesiho-tang(Dachaihu-tang) water extracts (DSTE) have potent anti-obesity activities in a high-fat diet-induced obesity mouse model.
Methods :In this study, we designed three groups (normal diet group, high-fat diet group, high-fat diet plus DSTE group for 7-weeks oral administration).
Results :Increases in body weight were inhibited by 7-weeks oral administration of DSTE at a 500 mg/kg concentration in this animal model. Results from blood lipid analysis showed that the levels of triglyceride, total cholesterol and LDL-cholesterol were significantly lowered by DSTE administration, also HDL-cholesterol was increased more than high-fat diet-induced obese mouse. To understand the underlying mechanism at the molecular level, the effects of DSTE were examined on the expression of the genes involved in lipogenesis by real-time PCR. In epididymal fat and liver of DSTE-treated mice, the mRNA level of lipogenic genes such as sterol regulatory element binding protein 1 and fatty acid synthase were decreased, which was well correlated with the reduction of the tissues weight.
Conclusion :These results suggest that DSTE may have great potential as a novel anti-obesity agent.
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KEYWORD
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Daesiho-tang(Dachaihu-tang), Obesity, High-fat diet, Sterol regulatory element binding protein 1, Fatty acid Synthase
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